Stomatológ 2021, 31(2):31-35 | DOI: 10.69658/sto.2021.019

Xerostomia

Bohuslav Novák1, Amir Amiry Manesh1,*, Petra Havranková1, Saeid Nikjoo2, Miroslava Valová2, Peter Stanko1
1 Klinika stomatológie a maxilofaciálnej chirurgie LF UK a OÚSA, Lekárska fakulta, Univerzita Komenského v Bratislave
2 AA Klinik s. r. o., Hviezdoslavova 10, Holíč

Xerostomia or oral dryness is developed when the amount of the whole saliva is primarily reduced or even absent. Xerostomia has significant devastating effects not only on the oral environment but also on an individual's general wellbeing. It poses substantial challenges regarding diagnosis and treatment for both patients and clinicians. In recent years, several therapeutic strategies have been proposed to reduce patients' symptoms; however, xerostomia remains an unresolved complaint in human dental practice, especially among elderly subjects. BioXtra is a synthetic product that contains all essential salivary components to relieve the symptoms of xerostomia. In the present study, the effectiveness of BioXtra gel, mouth rinse, and toothpaste were examined on 20 patients who suffered from xerostomia. Based on the findings, BioXtra products can significantly improve the symptoms of patients after 21 days. However, further studies with a large sample size are highly warranted.

Keywords: xerostomia, mouth dryness, artificial saliva, BioXtra

Published: December 15, 2021  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Novák B, Manesh AA, Havranková P, Nikjoo S, Valová M, Stanko P. Xerostomia. Stomatológ. 2021;31(2):31-35. doi: 10.69658/sto.2021.019.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. ARANY, S., BENOIT, D. S., DEWHURST, S., OVITT, C. E.: Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo. Molecular Therapy. 2013; 21 (6): 1182-1194. Go to original source... Go to PubMed...
    2. BARBE, A. G.: Medication-induced xerostomia and hyposalivation in the elderly: culprits, complications, and management. Drugs and Aging. 2018; 35 (10): 877-885. Go to original source... Go to PubMed...
    3. BAUM, B. J., ALEVIZOS, I., ZHENG, C., COTRIM, A. P., LIU, S., MCCULLAGH, L. et al.: Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction. Proceedings of the National Academy of Sciences. 2012; 109 (47): 19403-19407. Go to original source... Go to PubMed...
    4. BRIZEL, D. M., MURPHY, B. A., ROSENTHAL, D. I., PANDYA, K. J., GLÜCK, S., BRIZEL, H. E. et al. Phase II study of palifermin and concurrent chemoradiation in head and neck squamous cell carcinoma. Journal of Clinical Oncology. 2008; 26 (15): 2489-2496. Go to original source... Go to PubMed...
    5. CHOI, J. S., SHIN, H. S., AN, H. Y., KIM, Y. M., LIM, J. Y.: Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction. Oncotarget. 2017; 8 (8): 13496-13508. Go to original source... Go to PubMed...
    6. DAWOOD, I. M., EL-SAMARRAI, S. K.: Saliva and Oral Health. International Journal of Advanced Research in Biological Sciences. 2018; 5 (7): 1-45. Go to original source...
    7. ESCOBAR, A., AITKEN-SAAVEDRA, J. P.: Xerostomia: an update of causes and treatments. In: Güvenç IA, editor. Salivary Glands-New Approaches in Diagnostics and Treatment. London, UK: IntechOpen; 2018. p. 15-36. Go to original source...
    8. FOX, P. C., ATKINSON, J. C., MACYNSKI, A. A., WOLFF, A., KUNG, D. S., VALDEZ, I. H. et al.: Pilocarpine treatment of salivary gland hypofunction and dry mouth (xerostomia). Archives of Internal Medicine. 1991; 151 (6): 1149-1152. Go to original source...
    9. GIL-MONTOYA, J. A., SILVESTRE, F. J., BARRIOS, R., SILVESTRE-RANGIL, J.: Treatment of xerostomia and hyposalivation in the elderly: A systematic review. Medicina Oral, Patologia Oral Y Cirugia Bucal. 2016; 21 (3): 355-366. 2017; 2017 (011217): 1-6. Go to original source... Go to PubMed...
    10. GUGGENHEIMER, J., MOORE, P. A.: Xerostomia: etiology, recognition and treatment. Journal of the American Dental Association. 2003; 134 (1): 61-69. Go to original source... Go to PubMed...
    11. HAI, B., QIN, L., YANG, Z., ZHAO, Q., SHANGGUAN, L., TI, X. et al.: Transient activation of hedgehog pathway rescued irradiation-induced hyposalivation by preserving salivary stem/progenitor cells and parasympathetic innervation. Clinical Cancer Research. 2014; 20 (1): 140-150. Go to original source... Go to PubMed...
    12. HOPCRAFT, M., TAN, C.: Xerostomia: an update for clinicians. Australian Dental Journal. 2010; 55 (3): 238-244. Go to original source... Go to PubMed...
    13. ISLAS-GRANILLO, H., BORGES-YÁÑEZ, A., FERNÁNDEZ-BARRERA, M. Á., ÁVILA-BURGOS, L., PATIÑO-MARÍN, N., DE LOURDES MÁRQUEZ-CORONA, M. et al.: Relationship of hyposalivation and xerostomia in Mexican elderly with socioeconomic, sociodemographic and dental factors. Scientific Reports. 2017; 7 (1): 1-8. Go to original source... Go to PubMed...
    14. JENSEN, D. H., OLIVERI, R. S., KØLLE, S-F. T., FISCHER-NIELSEN, A., SPECHT, L., BARDOW, A. et al.: Mesenchymal stem cell therapy for salivary gland dysfunction and xerostomia: a systematic review of preclinical studies. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2014; 117 (3): 335-342. Go to original source... Go to PubMed...
    15. JOSE, T., GEORGE, G. B., BABY, M., ALUCKAL, E., PADIYATH, S., KURUVILA, J. et al.: Xerostomia-An overview. Italian Journal of Dental Medicine. 2018; 3 (2): 39-42.
    16. KRISHNAMURTHY, S., VASUDEVA, S. B., VIJAYASARATHY, S.: Salivary gland disorders: A comprehensive review. World Journal of Stomatology. 2015; 4 (2): 56-71. Go to original source...
    17. MORTAZAVI, H., BAHARVAND, M., MOVAHHEDIAN, A., MOHAMMADI, M., KHODADOUSTAN, A.: Xerostomia due to systemic disease: a review of 20 conditions and mechanisms. Ann Med Health Sci Res. 2014; 4 (4): 503-510. PubMed PMID: 25221694. eng. Go to original source... Go to PubMed...
    18. MUÑOZ, C., MARTÍNEZ, A., FLORES, M., CATALÁN, A.: Relationship Between Xerostomia and Hyposalivation in Senior Chilean People. Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral. 2019; 12 (3): 123-126. Go to original source...
    19. NAGLER, R. M., BAUM, B. J.: Prophylactic treatment reduces the severity of xerostomia following radiation therapy for oral cavity cancer. Archives of Otolaryngology-Head & Neck Surgery. 2003; 129 (2): 247-250. Go to original source... Go to PubMed...
    20. ORELLANA, M., LAGRAVÈRE, M., BOYCHUK, D. G., MAJOR, P., FLORESMIR, C., ORTHO, C.: Prevalence of xerostomia in populationbased samples: a systematic review. Journal of Public Health Dentistry. 2006; 66 (2): 152-158. Go to original source... Go to PubMed...
    21. PORCHERI, C., MITSIADIS, T. A.: Physiology, pathology, and regeneration of salivary glands. Cells. 2019; 8 (9): 976-995. Go to original source... Go to PubMed...
    22. PRINGLE, S., VAN OS, R., COPPES, R. P.: Concise review: Adult salivary gland stem cells and a potential therapy for xerostomia. Stem Cells. 2013; 31 (4): 613-619. Go to original source... Go to PubMed...
    23. RILEY, P., GLENNY, A. M., HUA, F., WORTHINGTON, H. V.: Pharmacological interventions for preventing dry mouth and salivary gland dysfunction following radiotherapy. Cochrane Database of Systematic Reviews. 2017; 7 (7): CD012744. Go to original source... Go to PubMed...
    24. SACON, M. B., ESTEVES, C. V., FLOREZI, G. P., GONÇALVES, A. F., PANNUTI, C. M., JUNIOR, C. A. L.: Comparison of two methods for sialometry: weighing and volume techniques. Clinical and Laboratorial Research in Dentistry. 2017; 2017: 1-7. Go to original source...
    25. VAN DER PUTTEN, G. J., BRAND, H. S., SCHOLS, J. M., DE BAAT, C.: The diagnostic suitability of a xerostomia questionnaire and the association between xerostomia, hyposalivation and medication use in a group of nursing home residents. Clinical oral investigations. 2011; 15 (2): 185-192. Go to original source... Go to PubMed...
    26. VILLA, A., CONNELL, C. L., ABATI, S.: Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag. 2014; 11: 45-51. PubMed PMID: 25653532. eng. Go to original source... Go to PubMed...
    27. WIENER, R. C., WU, B., CROUT, R., WIENER, M., PLASSMAN, B., KAO, E. et al.: Hyposalivation and xerostomia in dentate older adults. Journal of the American Dental Association. 2010; 141 (3): 279-284. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content