Stomatológ 2026, 36(1):18-22 | DOI: 10.69658/sto.2026.004

Chronic Nonbacterial Osteomyelitis of the Mandible in a 9-Year-Old Patient: A Case Report

MDDr. Andrej Bublák, MDDr. Sarah Kalmanová, MDDr. Mária Michálková, MDDr. Rastislav Juríček, MDDr. Denis Hrivnák, MUDr. Dušan Genšor, doc. MUDr. Mária Janíčková, PhD., MPH
¹Klinika stomatológie a maxilofaciálnej chirurgie JLF UK a UNM, Martin, ²Klinika detí a dorastu JLF UK a UNM, Martin

Chronic nonbacterial osteomyelitis (CNO) of the mandible is a rare autoinflammatory disease primarily affecting children and adolescents. Prolonged diagnostic delay — typically 11–15 months — results from a nonspecific clinical picture mimicking bacterial infection, in the absence of fever, positive cultures, and significant inflammatory laboratory markers. We present a case of a 9-year-old female patient with recurrent inflammatory involvement of the mandible. After several months of unsuccessful antibiotic management, CNO was histologically verified. Retrospective scoring according to the EULAR/ACR 2025 classification criteria reached 91 points (threshold ≥55), unequivocally confirming the diagnosis. Treatment with pamidronate combined with rheumatological follow-up led to progressive bone healing. The case highlights the need for a multidisciplinary approach and the inclusion of CNO in the differential diagnosis of inflammatory jaw diseases in children.

Keywords: chronic nonbacterial osteomyelitis, mandible, children, pamidronate, CRMO, EULAR/ACR 2025

Published: June 1, 2026  Show citation

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Bublák A, Kalmanová S, Michálková M, Juríček R, Hrivnák D, Genšor D, Janíčková M. Chronic Nonbacterial Osteomyelitis of the Mandible in a 9-Year-Old Patient: A Case Report. Stomatológ. 2026;36(1):18-22. doi: 10.69658/sto.2026.004.
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