Stomatológ 2019, 29(1):22-27 | DOI: 10.69658/sto.2019.005

Medication-related osteonecrosis of the jaw - How to prevent the complications?

Katarína Mikušková*, Dagmar Statelová, Mária Janíčková, Ján Staško, Zuzana Frličková
Klinika stomatológie a maxilofaciálnej chirurgie JLF UK a UNM v Martine

Medication-related osteonecrosis of the jaw (MRONJ) is a serious complication that affects patients treated with antiresorptive, antiangiogenic and cytostatic therapy. In order to avoid this complication, it is necessary to take a careful and targeted medical history before each tooth extraction. The authors of this paper offer instructions how to identify the patients at risk of MRONJ and recommendations how to proceed in prevention of medication-related osteonecrosis in patients at risk.

Keywords: medication-related osteonecrosis of the jaw, MRONJ, prevention of MRONJ

Published: June 15, 2019  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Mikušková K, Statelová D, Janíčková M, Staško J, Frličková Z. Medication-related osteonecrosis of the jaw - How to prevent the complications? Stomatológ. 2019;29(1):22-27. doi: 10.69658/sto.2019.005.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. JUNG, T-Y.: Osteonecrosis of jaw after antiangionenic agent administration in a renal cell carcinoma patient. Oral maxillofac Surg Cases, 2017, 3, p. 27-33. Go to original source...
    2. LASSETER, K., C., PORRAS, A., G., DENKER, A. et al.: Pharmacokinetic considerations in determining the terminal elimination half-lives of bisphosphonates. Clin Drug Investig., 2005, 25 (2), p. 107-114. Go to original source... Go to PubMed...
    3. MARX, R., E.: Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg 2003, 61 (9), p. 1115-1117. Go to original source... Go to PubMed...
    4. OTTO, S., PAUTKE, CH. et al.: Medication-related osteonecrosis of the jaw: Prevention, diagnosis and management in patients with cancer and bone metastases. Cancer treatment reviews, 2018, 69 (2), p. 177-187. Go to original source... Go to PubMed...
    5. OTTO, S., RISTOW, O. et al.: Fluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw: A prospective cohort study. J Cranio Maxillofac Surg, 2016, 44, p. 1073-1080. Go to original source... Go to PubMed...
    6. OWOSHO, A., A., BLANCHARD, A., LEVI, L. et al.: Osteonecrosis of the jaw in patients treated with denosumab for metastatic tumors to the bone: A series of thirteen patients. J Cran Maxillo Fac Surg 2016, 40 (2), p. 265-270. Go to original source... Go to PubMed...

    This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0), which permits non-comercial use, distribution, and reproduction in any medium, provided the original publication is properly cited. No use, distribution or reproduction is permitted which does not comply with these terms.


    Return to the content